As you work with MDF, you will know how it hates water. You could use it internally, but it would need to be THOROUGHLY waterproofed, because the slightest amount of water will cause it to swell. My own method of waterproofing any timber I use in a hull is to coat it with fibreglass 2 part resin, both inside and out, which I have found to be extremely effective, and since using this method, I have never had a timber hull leak. Because we live in a warm climate, I reduce the amount of hardener, which slows the setting time and allows me to complete a job before the resin starts to harden.
I'm sure many on this forum will have other ideas on the subject.
Peter