RC John is right, people who are totally left handed are rare, but there are reasons for this. I'm left-handed with almost everything, but I hold a knife in my right hand when eating. The reason for this, is that my parents taught me how to hold knive & fork before they realised how left handed I was, it can be very difficult to tell with children in their formative years. I've never bothered with any left handed items like scissors, you just have to get used to using them slightly differently to get them to work properly. I can remember being made to hold a pen in my right hand at school and finding it very hard, my parents had to write a letter to the headmaster to get the teachers to allow me to do it my way. To get back to the point of this thread though, I've never had problems with RC transmitters, but when I started flying, there were two modes in common use, throttle left & throttle right, or modes one & two. I used both for different models and never had any problems remembering which one I was flying with at the time, so in that respect I suppose I must be ambidextrous. I still use both modes today with boats, and as most model boating is about a million times easier than flying fast planes, having transmitters set up in different ways has never caused a problem. It's easy to swap ratchets over on stick assemblies, but I've never bothered. I can't work a computer mouse with my right hand though.