Most (full-size) single-screw vessels employ a RH prop. A RH prop at model size will tend to unscrew itself during use unless you have a LH thread on the shaft. Think about it - motor rotates clockwise viewed from aft and drag on prop tries unscrew it.
However, assuming you do not have a LH shaft thread, either a lock-nut on the shaft, a grub screw or Threadlok or any combination of these, will ensure this is very rare event.
Barry M