I have had an Epson R220, a Lexmark all in one,HP all in one canon all in one and now have the Epson Stylus Photo P50 , the epsons have only had epson ink because they came with them , apart from that its been compatibles , the all in ones got dumped after cartridges got used , I only paid about £30 for the all in one printers the inks came to about £70 , The two epson were bought for roughly £90 each the inks come to about £5 for a set of six but that comes down the more sets you buy , or as I said earlier and Mark said a couple of posts up a CISS system is the way forward just buy your bottles of ink and top up the CISS bottles