For me personally I have more have allergy issues with the dust created by cnc routers, I recently set up a CNC Shark pro and the noise was unbearable (laminate trimmer type) also I have alot of shapes to cut that have square internal corners.
Also there is no need for clamping the material down with the laser which is great for small pieces of work.
As to the toxicity, I get no smell inside the actual workshop and I stick to cutting well known materials such as timber, MDF, plywood, acrylic and styrene.