3M 4279 for me for most things, air fed if using 2K (Isocyanate based) at any point when there's open paint tins.
The 4279 has a particle pre filter backed up by carbon vapour filters, very effective and lasts a long time in hobby use. They are comfortable, fit to the face well (mine anyway), and can be serviced if needed. I just replace them every now and then though.
Air fed is the only way with isocyanates, drawn from a clean air space via a dedicated compressor, filtered and dewatered, the positive venting is absolute. Most are now full visors these days which is safer with the eye protection, but a real pain for detail work, so I've been nurturing an old oxygen mask type for very many years now for the detail work, my shop prescription glasses do the eyes.