Used both Spektum and Frsky. They both work well. I had to replace the encoder in the Spektrum DX6i- a known issue for going bad, only a pound for a new bit off fleabay. I use the Spektrum with the Orange and lemon cloned receivers, and they've never missed a beat, clearly others mileage may vary.
I would definitely say that Frsky is the way to go if you're looking for an upgrade. The Open TX operating system is totally flexible, and easy to understand once you've learnt a few basics, and the hardware is as good as any of the more expensive brands. I have one of the little Taranis X-lite's, a cute little handset like a bigger Playstation controller- nice set if you're a thumber rather than a pincher on the sticks. The X9D Andy mentions is a proper grown up size set, and offers a few more controls if you feel you need them, I'm personally happy with six proportional controls the x-lite gives you and like the small form factor.
As the Frsky sets use tuner modules, you also have the option of fitting a Spektrum or multiprotocol module if you want to retain backwards compatibility with your old Spektrum kit.